18-year-old Billie Eilish stole the show at her first Grammy Awards with five wins, toppling Lizzo's eight nominations.
The ceremony and its performers also paid tribute to basketball icon Kobe Bryant, who died in a helicopter crash just hours before the show. His 13-year-old daughter Gianna and seven others were also killed.
"Tonight is for Kobe, I'm crying [because] I love you," Lizzo declared, dedicating her performance of 'Cuz I Love You' and 'Truth Hurts' to the late NBA legend.
The sentiment was echoed by host Alicia Keys.
"We never imagined in a million years we'd have to start the show like this. Never, never, never, never," Keys addressed the audience, before honouring Bryant with a moving musical tribute alongside R&B group Boyz II Men.
A tribute performance for rapper Nipsey Hussle, who died aged 33 in a shooting last March, also honoured Bryant and his daughter.
"Rest in peace Nipsey Hussle, rest in peace Kobe Bryant, Gianna," DJ Khaled announced.
The awards were dominated by newcomer Eilish, the teen scooping up Best New Artist as well as Album of the Year, Best Pop Vocal Album, Record of the Year and Song of the Year for When We All Fall Asleep, Where Do We Go? And 'Bad Guy' respectively.
In the dance/electronic category, Aussie hitmakers Rufus Du Sol and Flume missed out with the Chemical Brothers single 'Got To Keep On' scooping Best Dance Recording and their album 'No Geography' winning Best Dance/Electronic Album.
'Old Town Road' hitmaker Lil Nas X, 20, also made an impressive Grammys' debut with six nominations, the rapper taking to the stage to perform his 2019 hit alongside Billy Ray Cyrus. He went home with two awards.
Pop superstar Ariana Grande, who was nominated in five categories, missed out.
Demi Lovato made an emotional comeback as she performed for the first time since an accidental overdose in 2018.
Michelle Obama was recognised for the audiobook of her memoir, Becoming, while Lizzo collected three awards including the Grammy for Best Pop Solo Performance for 'Truth Hurts'.
Check out the full list of Grammy winners here.